Return to Home Page Previous Page Next Page
Section 6  Herpes Simplex Virus (HSV) Infections
Section 6 Objectives
6.1.0  Biology of Genital Herpes
6.1.1  Pathogenesis of Disease
6.1.2  Epidemiology of Genital Herpes Infections
6.1.3  Clinical Manifestations of Genital Herpes
1.4  Laboratory Diagnosis Treatment, Available Medications Treatment, Available Medications Treatment Regimens Initial Clinical Episodes Recurrences Episodic Treatment of  Recurrent Infections Suppressive Therapy for Frequent Recurrences Intravenous Treatment
6.1.6  HSV in Pregnancy
6.1.7  Genital Herpes and HIV Infection
6.1.8  Counseling and Sexual Contacts
6.1.9  Prevention of HSV
6.1.10 Interactive web-based case
6.2.0  Review Questions
6.2.1 CME Credit Questions
6.2.2  References
1.0  Pathophysiology and Definition



Return to Home Page
Return to Home Page
Return to Home Page
Download PDF document
Return to Home Page
Return to Home Page
Centers for Disease Control Centers for Disease Control Home-Page
Return to Home Page
Anatomical Figures
Anatomical Figures Anatomy Figures Anatomical Figures
Anatomical Figures
Return to Home Page
Clinical Images
Return to Home Page

HSV Infections

1.5 Treatment

1.5.2 Centers for Disease Control Homepage Recommended Treatment of initial Clinical Episodes

Genital Herpes

Therapy shortens the course of illness by up to 7 days. Dramatic effects especially if medication is taken within 7 days of onset of illness and there is no history of oral HSV. The duration of pain and viral shedding is shortened, and the crusting of lesions occurs more quickly.


400 mg orally 3 times a day for 7 to 10 days



200 mg orally 5 times a day for 7 to 10 days


250 mg orally 3 times a day x 7 to 10 days


1 g orally 2 times a day x 7 to 10 days

Treatment may be extended if healing is incomplete after 10 days of therapy. Dosage should be increased to 400 mg 5 times a day in HIV infected patients (see subsection 1.7, for the management of HSV in HIV infected Persons)

Rectal Herpes or Stomatitis/Pharyngitis

Consider using higher doses of medication than for genital herpes. Higher doses used in treatment studies, but it is unclear if required.


400 mg orally 5 times daily for 7 to 10 days

Clinical experience is lacking for effectiveness of famciclovir and valacyclovir in treating proctitis or stomatitis, but they are likely to be effective.


Top of Page
STD/HIV Prevention Training Center of New England
Previous Page Next Page