Treatment of initial Clinical Episodes
Therapy shortens the course of illness by up
to 7 days. Dramatic effects especially if medication is taken within
7 days of onset of illness and there is no history of oral HSV.
The duration of pain and viral shedding is shortened, and the crusting
of lesions occurs more quickly.
400 mg orally 3 times a day for 7 to 10 days
200 mg orally 5 times a day for 7 to 10 days
250 mg orally 3 times a day x 7 to 10 days
1 g orally 2 times a day x 7 to 10 days
Treatment may be extended if healing is incomplete
after 10 days of therapy. Dosage should be increased to 400 mg
5 times a day in HIV infected patients (see subsection 1.7, for
the management of HSV in HIV infected Persons)
Rectal Herpes or Stomatitis/Pharyngitis
Consider using higher doses of medication than
for genital herpes. Higher doses used in treatment studies, but
it is unclear if required.
400 mg orally 5 times daily for 7 to 10 days
Clinical experience is lacking for effectiveness
of famciclovir and valacyclovir in treating proctitis or stomatitis,
but they are likely to be effective.